Holding alli Products

Use as directed.



alli®, along with a reduced-calorie, low-fat diet, can result in a 5% to 10% weight loss over time.

Learn more about how the product works. 

  • VO: Losing weight with alli® is easier when you know how it works. 

    VO: Although fat is part of a healthy diet, eating too much can cause you to gain weight. 

    VO: And while reducing fat intake is a really important part of your weight loss journey, using alli® with a reduced calorie, low-fat diet can help you lose that much more. 

    VO: When you eat a meal that contains fat, enzymes in your digestive system break down the fat into smaller particles that can be absorbed.

    VO: But when you take alli® before the meal, it attaches to some of those enzymes and stops about 25 percent of the fat from being digested. 

    VO: This undigested fat passes out of your body naturally, so you absorb fewer calories from what you eat. 

    VO: alli® works only in your digestive system, but to get the best possible results, you have to do your part. 

    VO: That means alli®, exercise and sticking to a reduced calorie, low-fat diet. And that’s how alli® works.

    Text: alli®

    VO: Stick with it, and steady, gradual weight-loss will be yours. Diet, exercise, and alli® — that’s all it takes.


  • alli® (orlistat 60 mg capsules) works by blocking the absorption of about 25% of fat in the foods you eat.
  • Since the calories associated with this unabsorbed fat are not used (1 gram of fat = 9 calories), the number of calories that enter your system is reduced.
  • Clinical trials have consistently shown that alli®, along with a reduced-calorie, low-fat diet to be more effective than diet alone.*
  • In fact, for every 5 pounds you lose with diet and exercise, alli® helps you lose 2 to 3 pounds more.*
  • alli® is only minimally absorbed into the bloodstream, so there are no direct effects on the cardiovascular or central nervous system. So you can take alli® knowing it won’t make your heart race or cause mood swings.
  • In clinical studies, most people lost 5 to 10 pounds over 6 months. Individual results may vary.

*alli® (orlistat 60 mg capsules) is for weight loss in overweight adults, 18 years and older, when used along with a reduced-calorie and low-fat diet. Follow label directions.


Because alli® works by blocking fat, you do need to eat some fat at each meal (if there is no fat in the meal, alli® capsules will have no effect). But it’s important to note that high-fat meals can increase the risk of diet-related side effects.

How to manage it all? Find balance. alli® is meant to be taken three times a day with well-balanced, reduced-calorie, low-fat meals. With alli®, each meal must be within your fat target to minimize the chances of diet-related side effects — generally, that’s between 12 and 18 grams of fat per meal. Find your fat target here.

alli® has the tools to help you lose weight. Get started with our weight loss guide.

Weight Loss Woman
Weight Loss Woman


Start your weight loss journey with alli® by reading these helpful resources.

alli Products

Use as directed.

alli Products

Use as directed.

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